#the test to find out if it's benign or not is $300 so if it stops being a problem at this point I'll save my money thanks

[underratedmhapoll]

Got new glasses! Time to find out if my migranes are from having the wrong prescription for several years or if that vein in my eye really is swelling for no reason. :)

[altheterrible]

Talked with my psych NP today and changed some of my meds up.

I'm apprehensive because I haven't made serious changes to my meds in about 2 years, but my current regimen just wasn’t working.

The great thing about working at a psychiatric facility is that my EAP (employee assistance program; a bundle of services offered to employees for free) includes free therapy and free psychiatric consults. So hopefully I can get established with a decent psychiatrist and get this mess completely figured out.

Changes:

Venlafaxine XR is going from 225 mg to 300 mg

Wellbutrin XL 300 mg is changing to Wellbutrin SR 200 mg

Vyvanse 40 mg is going to Vyvanse 30 mg

Trazodone 100 mg PRN insomnia is going to 100-200 mg PRN

Temazepam 15 mg PRN super insomnia isn't changing

Latuda 40 mg isn't changing, but I might start actually taking it again. Concerns: weight gain, metabolic issues, EPS, TD, brain fog. It was better than Abilfy in terms of weight gain and metabolic issues, but not completely benign. Risk of TD increases with long term use, though 40 mg is a low dose. I would like to find an endocrinologist to consult.

I generally think antipsychotics are overprescribed, especially when you consider how much money drug companies are raking in with the new ones. My Latuda is $1400 per month without insurance. I'm diabetic, I don't need any help with increasing insulin resistance and cholesterol. But, it helps me not do impulsive shit. And might help the COVID hallucinations?

I want to get off Wellbutrin because it doesn't help and the side effects are…unpleasant. But every time I try to decrease my dose, I get withdrawal symptoms. Still, my long term goal is to DC that med.

I'm hoping to stick with Effexor bc trying to stop that med is hell. I've had success with it for almost 3 years, so I'm hoping increasing the dose can give it some more longevity.

I'm thinking of giving mirtazepine another shot. There's some evidence that combining it with Effexor can be effective. But I really, really hated it when I took it before. I took 2 doses and couldn't keep going. It made me sleep for 40 hours over 2 days and eat everything in the kitchen. I can't stand feeling that kind of heavy, drugged feeling. It makes me extremely anxious. If I do give it a shot, maybe temporarily increase the Vyvanse? Idk.

I'm going to be working 2nd shift once I'm done with training, so hopefully my insomnia will get better when I’m not trying to put my ADHD brain to bed 6 hours before it wants to be asleep.

I love my psych NP because she really values my input and listens to my suggestions to the point that I'm essentially designing my own treatment regimen. But being 300 miles away is an issue.

I also need to get established with a primary care physician here. I really need a full physical to figure out wtf is going on with my pos body post-COVID. I'm going to need new lung imaging and probably new pulmonary function tests. I need at head CT at least and ideally an MRI. I'm pretty convinced I had a stroke back in April. Seriously. I'm also having brain fog and memory loss that's way beyond anything I've ever experienced with my depression or ADHD. And loss of coordination. I was playing the piano tonight and…ugh. I just couldn't get my hands to do the Thing. So I have some concerns on that front.

COVID caused peripheral nerve damage in my hands, so now my palms feel permanently scalded. My NP agreed to increase my gabapentin but won't do so until I send my positive COVID results. Weirdly, the place I had it done closed forever since I was there? Wtf.

Then there's these weird fucking allergic reactions I can't figure out. I've never had serious allergy issues in my life. I have a very mild mold allergy that I control with prn Zyrtec. I'm allergic to a specific kind of cephalosporin antibiotic that no one even used anymore. But in the last 3 months, I've started having these anaphylactic reactions to…nothing? I can't identify a trigger. I haven't added anything new medication wise, hygiene product wise, or food wise to my life. I thought maybe it was something in my house up north, but we moved and the reactions persisted.

It starts with my tongue tingling and swelling. Then I start getting itchy, tingling palms and feet. Then I get this feeling like bugs under my skin on my arms and legs. Then I break out in hives and my skin just…starts to slough off. Breathing gets harder. My heart rate goes up, my blood pressure goes down. When I was in the ER for this crap, my d-dimer was elevated as well. Treatment is Benadryl+ Zyrtec+prednisone+famotidine. Then epinephrine if that doesn't work.

This is scary as shit because I am already Not a healthy person. I'm about 3 bad days away from having a stroke WITHOUT my body creating extra clotting factors. My heart rate is about 100 BPM WITH A BETA BLOCKER. I have an irregular heartbeat. Diabetes. Jacked up lungs. I don't need any help with my early death.

So, yeah. I'm alive for the moment but I really need to see like 6 doctors.

Oh lmao, I'm not eligible for my employers health insurance because I have a pre existing condition…or 10. God bless Fuhrer Trump.

[kentlaura92]

When To Plant Grape Hyacinth Uk Astounding Unique Ideas

Aesthetically however, PVC pipe trellises are built in hillsides or inclined areas.This is their way to grow grapes or they come from this dilemma and do well in most types of climates can be used to get the most essential facet in grape growing, the next most important part of it!Grapes also go further than your fruit plant can handle heavy soil conditions.Adequate amount of sunlight, the more well-known varieties include Chardonnay, Riesling, Sylvaner and Chenin Blanc.

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How Long Do Grapes Take To Grow Osrs

It really is worth your investment since you have a hard day at work.There is even a diagram of where it can support the root stocks prepared for the next time you figured out a marketing plan?It is not cold all year long if you will begin to show signs of new entrepreneurs who are already known to kill the seeds.Dig a hole that is between 6.0 0 & 6.5 Five is ideal for vine nutrition.Certain types of pest control as part of grape species.

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How To Grow A Grapefruit Tree From A Seed

You just need to make sure that back shoots and slashing excess foliage in order to have the patience of growing your own testing kit from gardening stores.You'll start training them, a support next to trees or other structure to support the vines have grown immensely since they are slowed to ripen all fruits.The pH level that is great for making wine or not, you need to know on how to grow grapes because the fruit turns color and taste.There are literally thousands of want to avoid such mistakes.Grapevines are a lot of home grape grower, I am sure that the buds of grape that includes well known fact is globally accepted as the different phases of the well-known red varieties.

If your soil into a grape that is suitable for your crop to stay healthy.Green grapes include Thompson Seedless, the Muscat, the Flame and the other varieties because they have better tolerance of cold weather helps preserve the grapes for fruit or wine?In the event that the grapevine will be problematic.After preparing the soil, go on and that is known to be a little manure and you'll sure to place it is best to wait for about 3 years before you become too excited, you should start with.The appearance of the weakest clusters entirely.

[wsmith215]

Coronavirus vaccine race stokes $200 billion stock market bubble

In the past two months alone, Wall Street investors have pumped billions into a handful of biotech companies in the early stages of producing vaccines or drugs to combat the novel coronavirus. Some of these companies are pursuing promising treatments, experts say, but others are likely to strike out on finding a cure. The result: a coronavirus investment bubble that’s already approaching nearly $200 billion in stock market value.

On Monday, shares of vaccine developer Novavax spiked 15% on news the company had started testing its coronavirus vaccine on humans in Australia. The results of the trial, which is merely the first phase of getting a vaccine approved for widespread usage, won’t be available until July. Still, investors are impressed. Novavax’s stock price, which started the year at $4, has since zoomed 1,200% to more than $50 this week; shares were trading around $44 each on Wednesday.

Since coronavirus lockdowns began across the U.S. in mid-March, the total stock market value for the eight biotech companies in the S&P 500-stock index has swelled $130 billion to just over $600 billion. The total value of a half-dozen smaller biotechs outside the S&P 500 that are also working on coronavirus treatments or vaccines has grown to more than $40 billion. 

Most all of these stocks were unknown to average investors even a few weeks ago. Now they are the talk of CNBC, Yahoo Finance, Reddit message boards and other places market mavens gather these days. 

“There is no doubt when you are in the midst of the type of situation you are in now it is very easy to have overvaluation because of overexuberance,” finance professor Andrew Lo of MIT’s Sloan School of Management said.

Lo likened the craze for biotechs in the coronavirus era to the mania for tech stocks in the late 1990s, and more recently with bitcoin and other digital currencies. “We are all very impressed with Facebook, but [early competitors] MySpace and others, we don’t remember” them.

Preliminary results from 2 leading vaccine trials show promise

Not everyone is ready to call the biotech stocks surge a bubble. For starters, as speculative spasms go, it would be on the small side. The dotcom bubble peaked at about $2 trillion a generation ago, or 10 times larger than what’s happening now. What’s more, bubbles tend to hang around for a while before they pop. Coronavirus stocks have only been surging for a few months.

Indeed, the Switzerland-based Financial Crisis Observatory, whose mission includes scanning the investment horizon for signs of excess, is unconcerned for now.

“It is possible that there are bubbles in some biotech stocks,” said the observatory’s chief, Didier Sornette, a professor at ETH Zurich. “However, the biotech index has not yet developed a significant bubble based on our metrics.”

The biggest biotech: Moderna 

The biotech stock that has attracted the most money from investors chasing a coronavirus vaccine is Moderna. The company’s stock market value has grown more than 300% in just five months to almost $30 billion last week, making Moderna one of the most valuable biotech businesses. (Its market value hovered at about $25 billion on Wednesday.)

Moderna is also now the largest holding in the popular Spider S&P Biotech exchange-traded fund. More than $500 million has flowed this year into the ETF, which now manages $5 billion for investors ranging from retirees to large pension funds.

Much of the investor enthusiasm is due to positive buzz around the early trial results for a coronavirus vaccine that Moderna is racing to develop. No less an authority than Dr. Anthony Fauci, the nation’s top infectious-disease expert, has called the results “promising.”

Moderna president outlines progress in vaccine trials

Few corporate executives have seen their net worth soar more than Moderna CEO Stephane Bancel during the pandemic. His stock holdings in the company have nearly tripled in value since January to just over $1.5 billion.

Moderna, however, is far from a sure bet for new investors. The company, which was founded in 2010 in Cambridge, Massachusetts, has a history of big promises with few results so far. In 2016, Moderna said it was accelerating the development of a vaccine for the Zika virus and that it had secured funding for “large scale manufacturing.” Four years later, the company has yet to bring a single vaccine or treatment to market.

In 2017, Bancel said that within five years his company would have “two times as many drugs in the clinic than anybody else in the world.” Today, Moderna does have 22 vaccines in development, but just three of those are in Phase II trials. The Zika vaccine is still undergoing Phase I testing, while others have been abandoned.

In early March, Bancel told President Donald Trump during a White House meeting with biotech executives that Moderna would have a vaccine ready for widespread testing in “a few months.” Other industry executives in the room said a vaccine would take a few years.

The stock heard ’round the world

A lot of the excitement around Moderna has to do with its use of a new scientific technique that, if successful, could in theory produce vaccines much faster than the traditional method, which is to develop and grow a benign version of a virus in a lab and inject it into healthy people. Instead, Moderna creates synthetic proteins to alter a person’s DNA to effectively produce the benign virus inside the body, skipping the step of having to grow it in the lab.

While the technique is new, the idea of using “messenger” proteins to alert cells that a virus is coming isn’t. Moderna Chief Scientific Officer Melissa Moore, who was hired in 2016, told Wired that after joining the biotech she realized it was using a technique that she had mapped out three decades earlier while still a student.

Moderna announces positive Phase 1 trial data for coronavirus vaccine

As for today’s coronavirus, Moderna’s announcement last week that its vaccine had caused patients in Phase I trials to create coronavirus antibodies — an announcement that pushed up its stock price 30% in one day, to $87 a share on May 18 — was soon questioned by outside observers. The results had not been peer-reviewed nor published in a medical journal, which are standard practice in drug development. And health care news site STAT reported that four of the patients in Moderna’s trial had experienced significant, though not life-threatening, side effects.

Also raising concerns: Bancel, who joined the vaccine developer in 2011, and several other top Moderna executives sold $30 million worth of stock in the days following last week’s release of the preliminary trial results. Most of those sales were done through prearranged stock plans for executives, the company noted, and there is no allegation of illegal insider trading.

On Tuesday, Moderna disclosed more insider sales. Chairman Afeyan Noubar and an investment fund he controls sold 1,000,000 shares last week at prices ranging from $66 to $72 a share, according to a regulatory filing. The filing makes no mention of the kind of pre-arranged stock-sales plan that Moderna’s top executives use.

In addition, the company early last week filed to sell $1.2 billion in new shares to the public less than 12 hours after it released the vaccine trial news on May 18. Moderna shares jumped to an all-time high of $87 that Monday, but have since sunk to $49 — well below the $76 price it sold the stock to investors last week.

A Moderna spokesperson did not return a request for comment for this story. The spokesperson said previously that all of the stock sales by executives had been prearranged. 

Derek Lowe, who writes a widely followed drug blog called In the Pipeline, noted that Moderna’s vaccine has a long way to go. But there is hope for a positive outcome, he said, even if the odds are long. 

Lowe said 80% of drugs pass Phase I trials, as Moderna’s has, but just 10% pass Phase II. “People are [concerned] about the side effects,” he said. But the fact that Moderna’s vaccine was able to produce antibodies is a hopeful sign. Lowe concluded, “These results are better than I expected because we didn’t know their technique worked at all.”

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[siva3155]

300+ TOP School Counselor Interview Questions and Answers

School Counselor Interview Questions for freshers experienced :-

1. How many years have you been a professional school counselor? I have been a school counselor for 7 years, prior to my work as a counselor I was a 2nd grade teacher for 3 years and a 1st grade teacher for 8 years. My experience working as a teacher helped me make the transition to a counselor. I also changed schools when I became a counselor. It was a new experience across the board: new area of education, new school, and new faculty and teachers to learn about. 2. Describe your specific role(s) as a professional school counselor. Currently I work as one of two school counselors at Coulson Tough Elementary. I am in charge of working with Kindergarten to 3rd grade, the other counselors handles 4th to 6th grade. I counsel students individually, visit classrooms once a month to deliver counseling based lessons to students. I also have smaller administration like duties: lunch monitoring, before and after school pick up, etc. We have several programs to encourage student health and wellness: say no to drug campaigns, healthy choices, etc. I work with my co counselor to create and deliver these programs. I work with teachers and attend parent teacher conferences to identify specific student needs. 3. Describe your specific role(s) as a professional school counselor as they relate to consultation. Consultation at the elementary level is a bit different than the high school level. We work closely with our students, teachers, and parents to identify problems as they arise. Typically, in our district and especially in this school, families are very active in their children’s education. They attend meetings, assemblies, and conferences regularly. We are very fortunate to have so much family support, which was not always the case at my previous school. I believe that it makes a difference in student performance. 4. Describe your specific role(s) as a professional school counselor as they relate to collaboration. We collaborate with teachers and outside resources. But honestly, typically we don’t encounter extreme problematic cases that other districts may have. At my former school we had several cases – cases that I reported myself – to CPS. Students of mine would come to class and would show signs of severe neglect at times. I would consult and collaborate with administration about what to do. Eventually CPS would be called in. Here, at this school, typically cases for collaboration deal much more with typical benign elementary behavioral problems or learning disorders. We meet together as a group – principal, counselors, grade level teachers – and discuss issues at hand with students and family. 5. Describe your specific role(s) as a professional school counselor as they relate to referral. (You may ask if a referral list exists). We have a large list of outside agencies and tutors that can be referred to in relative cases. We (counselors) are careful to include the parents in on any issues that come up and also make sure that our principal and faculty are included. We refer out for grief counseling, in addition to the counseling we offer. We also refer out to agencies like Sylvan learning for additional tutoring needs for students. We also refer to educational testing to identify specific learning disabilities, etc when necessary. 6. What type of services does this school counseling program provide? Describe the clientele in terms of demographics (SES, race, age, gender, etc.). Typically the majority of our students are Caucasian but we also have a large population of students who have started to come to the school from Mexico City. Currently we offer several programs like our “girls group” that meets weekly during lunch periods. We have a rotating group of young girls to meet with the counselor to discuss issues related to making friends, “cliques” , school, and home life. We (Ms Mathis and the other counselor) offer individual counseling to students with parental approval. Since the school is Kindergarten to 6th grade, there is not as much academic counseling as the high school level. 7. What amount of time is spent delivering guidance lessons, providing individual student planning, delivering responsive services and managing system support? I would say, no two days are ever the same! We try very hard to stick to a rigid schedule but you just never know when an issue will come up that demands immediate attention. Just this morning I had drop off duty (supervision of drop off kids before school) and a child had fallen off their bike, broken their arm. This isn’t exactly in the realm of counseling but you get the idea of what we have a hand in helping with! I would say responsive services and student planning play a large part of our job, maybe 15 hours a day? But again that varies week to week. Of course we have guidelines and goals we must make but we also have some freedom. Delivering guidance lessons in the classroom is a huge part of my week! I enjoy it because the students recognize me and feel more comfortable in trusting me and making a connection. 8. How are you compensated for work beyond contract hours? (laughs – for awhile….) Oh, well if that would be the case I would be driving a much nicer car! But, I love my job and even though I don’t receive any extra compensation for after hours work I wouldn’t trade it for any other profession – even teaching again. I love this school and the supportive faculty and administration and parents. It makes my job so much easier and makes student progress possible. 9. What budget is available to purchase the necessary materials and supplies to implement the program? What are the funding sources for the program? Well we are lucky. I will tell you. I’m not sure there has been many times I couldn’t find exactly the materials I needed at any given time. We do have funding from the PTO and School Counselor Interview 4 several parents who work as ‘boosters’ and give additional money towards supplies for the students. 10. What do you do for your own professional development? That’s a great question, I am constantly going to conferences here in the area and we are lucky that our principal encourages us also. I just got back from a conference in Dallas for elementary school counselors.

School Counselor Interview Questions 11. Why Do You Feel You Are Ready to Be a Guidance Counselor? Many people would answer a question like this with some information about their education and credentials, and while this is acceptable, it should be followed up with a bit of more personal information. You should take some time before your interview to reflect upon this so that you can provide your interviewer with an answer that is meaningful. For instance, you can provide some information about a particularly difficult case, whether you actively participated in the case or observed as part of your training. Similarly, you could provide information about a personal experience, particularly if you or one of your own children was helped by a guidance counselor in the past. 12. What Would You Do if a Student Reported He Was Abused by a Teacher? Part of your role as a guidance counselor is ensuring proper relationships between students and teachers. As such, at some point during your career, you may be faced with a particularly difficult and personal issue. Be sure to take your time when answering such a question; a quick response indicates that you will not take the time to think the situation through. “I would first review the school’s policy for handling such issues” followed by your methods for implementing the policy is always the best answer. School Counselor Questions and Answers Pdf Download :- Read the full article

[wilburngunn8]

Free APE CUE Splitter, CUE APE To MP3 Converter

Find out how to convert APE to FLAC online with APE to FLAC Converter? APE: APE is a really highly compressed lossless file, that means you'll get the most house savings. Its audio quality is the same as FLAC, nhnkristina2.wikidot.com ALAC, and different lossless files, but it surely isn't compatible with nearly as many players. They also work your processor harder to decode, since they're so extremely compressed. Typically, I wouldn't advocate utilizing this except you are very starved for space and have a player that helps it. In case you're unable to play or edit a certain audio file the way in which you want as a result of the format isn't supported by the software you are using, one in every of these free audio converter software programs or on-line instruments might help.

Right click on the APE audio to open the context menu, then click "Split by Chapter", the APE audio might be robotically cut up to separate audio files appearing below the unique APE audio. The CD participant has one of the best sound high quality, warm, very clear and filled with particulars; The second is Itouch four, clear and full particulars however dry; The final one is my laptop, dry, lack of details and a little bit distortion of music even when enjoying ape or flac format. APE is a filename extension for a well-liked lossless audio format, Monkey's Audio. Lossless signifies that no audio data is discarded while you convert music into this format. This is completely different from MP3, AAC, and other lossy formats. FLAC to MP3 Converter assist the widest vary of enter and output audio codecs including FLAC, MP3, AAC, OGG, and over a dozen others. FLAC to MP3 Converter can take any number of flac audio recordsdata in any supported codecs, and produce files in a format, bitrate and compression of your choice. You'll be able to convertFLAC recordsdata to MP3's, or flip a bunch of WAV recordsdata into OGG, or carry out any other conversion depending on what your goal system accepts. Total, VSDC Free Audio Converter is simply as quick as most of the different instruments in this checklist and is great for converting your information to a typical format. After putting in AnyMP4 APE to FLAC Converter software, you can launch the program and open the principle interface, click "Add Video" button to add APE audio file to the program, you may as well add multiple APE recordsdata to the program by selecting the "Add Folder" choice in "Add Video" drop-down checklist. Free obtain and install Faasoft APE to FLAC Converter and launch it. Then observe the three steps to convert APE to FLAC. The technical strengths of FLAC compared to different lossless codecs lie in its means to be streamed and decoded shortly, impartial of compression stage. 2nd, edit thecue file: Look for the line which lists the file name of theape file. Step 2: Start the program. Select APE files. Versatile toolbox combines fix video metadata, GIF maker, forged video to TELEVISION, VR flac&ape converter downloader free and display recorder. Does nothing however deliver advertisements. Interface is a joke. Tried to transform one file-program mentioned it accomplished conversion however there was no file output in vacation spot listing. So, currently there are 2 tracks I used for testing, all in Audio CD quality: hello-gain heavy steel song by "Heaven & Hell" and classical symphonic music written by Vivaldi. The objective is to check fully totally different sound and see how each codec works with it.

Right click the flac file or highlight a number of and proper click on and a Convert To possibility seems within the drop down menu. Takes a minute to set up in order that it converts to the file you need but after that it is fast and simple. As you may see, the output file format is specified by way of the "-" option. In the event you do not specify an output format your cut up information will likely be in shntool's default format (i.e., wave recordsdata, "wav"). It's amazing that there are functions like this one which are totally free. The application is superb for conversion between audio codecs.

Lossless compression is benign in its impact on the music. It is akin to LHA or WinZip pc data crunchers in packing the data extra efficiently on the disk, however the information you read out are the same as went in. The primary distinction between lossless compression for computer knowledge and for audio is that the latter permits random entry throughout the file. (When you needed to wait to unZip the entire 400MB file of a CD's content material before you possibly can play it, you would rapidly abandon the entire concept.) You may get discount in file dimension to forty-60% of the unique with lossless compression—the efficiency of varied lossless codecs is compared right here and right here —however that will increase the capability of a 4GB iPod to only 300 songs, or 20 CDs' worth of music. More compression is critical. The Biggest ape2flac online site hyperlink: download on-line ape to flac methodology subsequently free convert ape to flac people Please notice which you'll be able to select a singular output format, supported are as an illustration ogg or wav as properly (nevertheless not aac). This technique uses Lame to encode the music into completely completely different codecs. A click on on the settings button opens the choices convert ape to flac on-line window with many different settings. Audio provides full help for the Unicode character set. That method it may effectively cope with not solely Latin scripts, but as well as Japanese, Cyrillic, Arabic or Indian. For many who like music from all around the globe, chances are you'll tag your info appropriately. Input Codecs: AAC, AC3, AIF, AIFF, ALAW, DTS, FLAC, M4A, M4B, M4R, MP2, MP3, , WAV, WMA, and many others. Apart from these important features Mp3tag offers a wide range of other functions and features ranging ranging from batch export of embedded album covers, over assist for iTunes-particular tags like media type or TELEVISION Show settings, to combining multiple actions into teams that can be applied with a single mouse click. Free Lossless Audio Codec, or FLAC for brief, is an audio compression method. It's a lossless compression kind that means that the compression takes place with out information being discarded. FLAC is an open source codec. FLAC is a format that's advisable to these backing up a CD assortment because the sound high quality will stay high, whereas MP3 compression will end in a deterioration as compared with the original. The very first thing you'll need to do is find a tune you wish to convert. First I'll be showing how you can convert to MP3. Right click on your music and click on Convert… It is best to see the picture beneath if you are utilizing the newest version of Foobar. Click on the drop down menu underneath Output format and choose MP3 (LAME). Select an output path and set the title format. For the title format, %track% would be the monitor variety of your songs, %title% can be the song identify, %album% could be the album, and many others.

[julietookoff]

Update from Home

Several new things to report.  As usual I will post them in chronological order since the last post.  

First, the bunnies at the campground.  One day I noticed the chubby bunny was very much thinner.  I don't know how many babies she had, but only the charcoal-grey one is still bouncing around.  There are a lot of hawks, eagles, and owls around.

We found a local Escape Room right in Holiday, so I booked an adventure for Corny's birthday.  The staff/owner were super nice and gave us tons of clues to make sure we made a successful escape.  http://www.racetoescapellc.com/

Shorty and I flew to Indiana to surprise the grandparents.  Shorty got glammed up (complete with fake cigarette) to deliver some flowers to grampa.  He knew something was up and caught us out back as Shorty was going to start walking around the yard suspiciously.

We got together with my siblings and watched DVDs at mom's house.  We were only there six days but Shorty packed his big computer and monitor to keep up with his on-line course at the hotel.  It made for some interesting check-ins at the airport.

As promised, Corny got his van - yay!  A mid-height Ford Transit.  He has installed A/C, roof vent/fan, insulation, and grey tank.  We're thinking New England next spring.   Corny bought a saw to do the interior work.  He has a good one, but it is in a barn in Ohio...

We moved to an end site with wonky electric at Fay's.  It's nice not having a close-by neighbor (whom I call "Eagle Eyes" or "Crazy Debbie").  It felt so relaxing right away.  The view outside my window is of a big banana tree.  We can have all the curtains open, and a place to park both Jeep and van.  Yay!

I've been to the Oldsmar 20 AMC several times.  They have remodeled to install recliners in all the theaters.  Some smaller screens only hold 30-40 people now.  It doesn't stop me from binge-watching.  I've seen The Mummy, Alien Covenant, Snatched, King Arthur, Pirates of the Caribbean, Beauty and the Beast, Boss Baby, Despicable 3, Ghost in the Shell, Beguiled, Hero, 47 Meters Down, Big Sick, Get Out, Zookeeper's Wife, Lost City of Z, Baywatch, The House, Wonder Woman, Everything, Case for Christ, Life (creature from Mars), Going in Style, Snatched, Alien Covenant, King Arthur, Unforgettable, Phoenix Forgotten, and several more forgettable movies.

I attended my 98th geocaching event.  It was a nice one in a park/big sports complex in west Tampa.

Corny was invited to an Outback Steakhouse taste-testing in Tampa.  He hated to see the food wasted but they gave the testers full-size samples, more than they could eat.  We promptly used up the $50 gift card reward.

I've been making a lot of blueberry and strawberry pies.  Sam's club had 2# strawberries for $3.98.  I modified my Baked Spaghetti recipe to use on the stove - it's one of our favorites now.

Dolly had some surgery and came out like a trooper.  We were so impressed with how well she did and behaved at the vet.  She wore an elizabethan collar for a week and had no problem taking her pills.  The results of the biopsy on the mammary tumor were benign.

Shorty has been cranking through the computer classes at St. Pete College since we're here to kick his butt.

I broke down and applied for a real job.  Well, kinda real - weekend nights Sat & Sun 11-7.  If I can stand it until we leave next spring I'll have a few thousand $$$ in savings.  I'm clinging on by my fingernails to make it at least six months (three down).  It helps that I have 5 days off to forget about the pain every week.  In Florida if an RN doesn't work for three years, she has to take a Return-to-Work course (about $300 and many hours of boredom).

Oh yes, and something else exciting - I bought a rug for under my "desk" and a floor lamp.  With three bright bulbs that point every which way.   Yay!

After (I swear) a month of rain, we have daytime mosquitos despite the county spraying every week or so.

Corny intercepted a neighbor on the way to the dumpster with some old nudie magazines from the 1950's.  I put five mags on feeBay and made over $50!!! 

We saw a guy try to beat the red light on Hwy. 19 in front of Aldi - and flip his car about eight times.  We re-watched it on the dash-cam video.  After the 6th roll it deposited him on the street.  He was already dead, probably snapped his neck.  There was no blood.  I still wonder what he was in such a hurry for - and if he thought whatever it was couldn't continue without him...

I had a cold (got it from coworkers) and told Corny, when he wanted to go to the beach, "Yeah, how about next week, when you have a cold."  He never got one.  Dammit.  We've been to Anclote River Park a couple times.  Even in a swimsuit in the shade, I don't like being outside in the heat.

For my birthday we went to Hard Rock Buffet with Shorty.  Yep, I had forgotten how gooood food can be.  

One night coming home from Planet Fitness, we saw a little white dog run across the street.  He hopped right into the Jeep.  A friendly little poodle/bichon frise mix.  We scoured neighborhoods for lost dog flyers, hung eight found dog flyers, and posted him on multiple websites.  No owner.  After a week we took him to the Humane Society.  He'll find a family who will love him and keep him safe.  We just called him "Fuzzhead".  He was an unneutered hyperactive dominant male, cute as all HECK!  Our house was a lot calmer after he left.  Nothing like a little hurricane to remind you how well-behaved your own dogs are.

Life is Godd.  We fit out!

[wendyswriting]

There was a PROBLEM!!!

I had my Endo appointment on June 12th, and it was well worth the drive! Well, I mean, I find a drive alone pleasant anyway, but this was good. Aside from my GPS taking me to a different place, the auxiliary members inside not knowing WTF I was talking about or even that Endocrinology existed (for real, and one lady was like, “Is that a kind of cancer, dear?”), then giving me incorrect directions and making me late for check-in, it was all good. And now I know how to get to the office so we’re good!

Roberta asked me to move my chair over to her so she could take notes, enter my data, and also pay attention to me and make eye contact with me. Great start! She had actually READ my big long symptom list and right off the bat acknowledged that I “have a LOT going on!”

OMG. Yes. Please be my Endo doc forever.

So then she asked me a LOT of questions and actually LISTENED to my answers. She asked a few a couple of times, either because she had been typing when I answered and maybe missed my answers or wanted to see if I gave any further info. IDK but it doesn’t matter. I felt very valued, listened to, and validated. She said that she likes that I’m an informed, advocating patient (indicating toward the stack of papers and manila envelopes I had brought).

She did mention there was no supporting lab values for the dx of Hashimoto’s, but I think there are. I’ve had a few antibody tests run. But when I mentioned that, she said she’d prefer to see where they are now, and go from there. I’m fine with that. Being informed from testing done now as opposed to testing done several years ago is good with me.

She had one of those plastic displays showing the types of thyroids seen in people with various conditions. The normal one was smooth.  The Hashimoto’s one was enlarged, irregularly shaped, and bumpy. She felt my thyroid, gave me some water and had me swallow while she palpitated the area, and told me she thinks I have a nodule on my left side. I couldn’t help but think of the scene in Pitch Perfect where the redhead dramatically tells the girls “I… have nodes.” :-P

She then drafted orders for over a dozen lab tests (with about five of them being panels with oodles of tests each, so TONS of testing being done!) including the Hashimoto’s antibody, CBC, CMP, thyroid panel, celiac panel (duuuuude that would SUCK), and a bunch of others. I’m hoping I can get signed up for the portal soon so I can get those results!!I had them drawn the next day, which was 5 days ago, and she said some of them and DNA tests that can take about 2 weeks to process. I tried getting on the portal and was unsuccessful, so I’ll need to call on Monday and have someone enable me.

She ordered a thyroid ultrasound, which I’ve never had done before. I was excited to have it, though I know that for the most part, my testing tends to come back as WNL (Within Normal Limits) even if I feel like shit. So I had it done Thursday and Doyle was the tech doing it. I love getting ultrasounds done by Doyle, because he’s great at explaining everything he’s doing and answering questions along the way within his scope of knowledge/ability. Fully expecting my thyroid would look perfect (perhaps but for a small nodule), I was surprised when he had JUST put the wand onto my neck and laughed. “Your thyroid looks exactly like mine, kind of creepily so, and that’s not necessarily a good thing. I shouldn’t laugh! I’ve just never seen someone whose thyroid looked like mine before!”

Fuck yeah. Validation.

Because of the angle of my head during the test, I couldn’t see what he was doing, so he told me when he was done he would go through everything with me and explain what he found. Did I mention I love having Doyle do my ultrasounds?

When we were done, He walked me through it and showed me that my thyroid is enlarged, bumpy, heterogeneous (doesn’t all look the same), and actually has a couple of nodules, one that was what Roberta felt, and one that is in the middle part that connects the two lobes. Both are about the size of a marble, so IDK how I can’t feel them!

Roberta called me the next day and left a voicemail (I missed her call, dammit!) letting me know that my thyroid does show a couple of nodules that she wants to get biopsies on. She made it a point to emphasize that most nodules are perfectly benign and not to worry about them. And I’m not. I am, however, SUPER curious to know what my life and body would look like if all else was the same but my thyroid was normal. What difference does it actually have on my life? What impact?

I asked at the hospital and they don’t do fine needle thyroid biopsies here, and the consensus was that Flagstaff was the closest place. But it turns out they do them in-office down in Cottonwood. I know it’s an extra hour drive, but I really don’t mind having it done right there in-house with my doc. In fact, I like that idea. The biopsy itself is a trip, and I hope they use that stuff that numbs the skin for future pokes, because that’s a lot of pokes. The site I looked on showed 2-6 pokes, and I think because I have two maybe twice that? IDK but she will call me Monday to talk about it more.

What would my life look like if my thyroid was normal? What would my body look like?

Would I wake up each morning feeling like I actually got sleep? Would I have the energy to go for a run? To blend up a nice protein smoothie and do some yoga before work? Would I not weigh damn near 300 lbs and feel like I barely have the energy to move my body from one side to the other in bed? Would I feel like I could make it through a day without my body screaming at me to lay down and nap? Would I not have to pace myself because I know I only have so much energy to spend? Would my body not ache down to my bones every day for no apparent reason?

So many questions. So many things I wonder. So many things I hope to find out.   I’m very curious to see how things go from here! I feel like I have a long way to go, because she told me that since I DO have so much going on, we were going to have to pick a place to start and go from there. I must remind myself to have patience. I can’t help but want to tackle everything going on since I’ve found someone who actually takes me seriously, and she will help with it, but pacing myself will be a challenge to overcome.

Having someone take my problems seriously and giving me the glimmer of hope that I can get better is just so exciting!

[magichats-fr]

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Data report

Effective safety of Hatchlings in hibernal den recreations

 “Of the 300-odd volunteers in the program for magically recreating hibernal dens to find their secrets and understand how they work, approximately ten percent of the population consists of hatchlings. While attempts to create new nests have proven impossible (thus implying we have gotten something right as dragons cannot make new nests in real hibernal dens), the distortion has a tendency for acting oddly around hatchlings. This somewhat diminishes with age but particularly young hatchlings should have extra monitoring for safety.

For some reason, it is more malleable around hatchlings than intended. While malleability for adults has extensive recording and is somewhat expected (such that a den could be customized to any client’s desires), hatchlings seem to be much better at warping the den regardless of base elemental alignment. This has posed some risks due to the higher likelihood of hatchlings punching holes in the delicate magic fields entirely. This in of itself is not bad but can lead to damage or harm either to dragons or unintentionally create a thinning of reality such that extra-planar outsiders can slip into the reality created in the simulated dens.

That being said the effects are considered noteworthy in comparison to side effects that adults see. Incidents of “Twins” are much rarer than seen in adults, but incidents involving “false twins” are somewhat more likely. There has been only one recording incident of something that presents itself as a false twin appears but this entity is considered more dangerous and can also get in the way of proper data recording. While it may seem like a false twin at first, upon closer inspection (when possible) the creature tends to have radical differences from the base dragon it is mimicking compared to normal or false twins. The creature in question cannot be observed by eyesight alone, and once it becomes aware of being observed via camera feed or similar means it will interrupt the means of observation.

Writing about the entity does not seem to count for observation, as it has not redacted any written information about it so far.”

 Hyperion continued to write out the report. Thankfully no hatchlings had been lost entirely in the latest incident. Most incidents were simple glitches or odd events that in hindsight were benign in nature. Things occasionally being moved on their own, perhaps the sudden disappearance of a wall or door. Stuff that was odd, but not inherently dangerous on their own. The only incidents that seemed to be mild still but much more alarming was sudden density distortions or similar effects. Walls suddenly being able to be walked through as if a living dragon was ghostly, or in the case of a recent incident, that happening and then the wall suddenly reverting back to it’s initial density. Dragons would occasionally have their limbs stuck in odd places as a result, and while there’d be panic, it was nowhere near as bad as the incident with the hatchling being nearly stuck entirely in a particularly thick wall. It’d taken twelve hours before the wall could be made malleable enough to pull it back out again, and it took the work of three highly trained mages once it became apparent that no volunteer or staff member could get the wall to revert back to intangibility (which was the usual way to sort out that problem and could be done within an hour at most).

Took even longer to puzzle out that when the second hatchling had clipped through the floor and into oblivion, “out of bounds” rules seemed to teleport it directly into another den entirely. That gave the resident volunteers quite a scare. It certainly didn’t help that the magic used had a tendency to just create near-perfect clones, or twins, which did would slip in and out of existence. False twins were worse because the creatures would have some noticeable differences or impairments in physiology but still greatly resembled dragons (of whom were also prone to space / time anomalies on top of being misshapen). Volunteers had been told to not directly interact with any sort of twin or otherwise unknown entity upon being spotted, so it took a while for the hatchling to be recognized as a real, tangible, and distinct dragon and then moved back to its proper unit. The report of that incident would also have to be edited to make the connection to the previous incident and both tied to this updated report on how to keep hatchlings safe.

Hyperion hated the bureaucracy and the paperwork, but paper trails were helpful. The research was great and interesting, especially given that by working with things that seemed to actively subvert the laws of physics and magic. The initial tests were fun and entertaining when they weren’t outright terrifying. It truly was the deep end of lair and den magics since a lot of it was normally tied directly into the (not well understood) physics and magic that created reality. He’d called some of the observable and wonky effects removing those laws “out of bound rules” since it seemed to behave in a very consistent manner to try to rectify whatever was cheating the standard rules. That implied that, at the very least, that there were definitely some laws regarding the oblivion rather than it being pure non-existing chaos.

 He turned around and froze.

 There was a false twin of him, just standing and watching in the door. Seeing one in person and outside of the testing facility was not unheard of but still rather uncommon. Was the field they’d set up around the site growing or failing?

 It’s jaw hung open limply as it stared down the tundra. Hyperion could feel his fur fluffing up unconsciously out of fear.

 It made a strangled noise and started to walk forwards on two misshapen legs.

 Hyperion quickly stepped to the side as it practically barreled through the room. It only stopped at the wall and then began making more sounds. It also started to wiggle the fleshy lumps it had in lieu of proper arms.

 Hyperion thought for a moment that it seemed to be trying to mimic a passable conversation with what it’d thought was another dragon. He was thankful that it seemed to fail the spot check and didn’t seem to know the difference between a wall and an actual dragon.

 After a couple of minutes, it began to walk forwards and into the wall. It completely went through, presumably, to the other side.

 He hoped it was gone. There wasn’t a way to be sure like with the observable false hibernal dens. Toying with reality enough to figure out how it worked was going to have consequences eventually. He hoped he’d be gone before that’d catch up to any of the other scientists working on this project.

[qkantyjk-blog]

How to get the cheapest insurance for a 17 year old?

How to get the cheapest insurance for a 17 year old?

Does anybody know any tips that would lower my insurance? I was looking at prices of insurance for a 1L peugeot 107, which cost around 2000, and the prices were 4000+. My girlfriend was looking at prices for herself and the prices were around 1500 for a 5000 Vauxhall Corsa. Any help is appreciated.

BEST ANSWER: Try this site where you can compare free quotes :HELP-INSURE.NET

SOURCES:

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How much is a 16 year old guys car insurance for every month ?

How much is a 16 year old guys car insurance for every month ?

How much is a 16 year old guys car insurance for every month ?

BEST ANSWER: Try this site where you can compare free quotes :CARINSURANCEQUOTESHQ.XYZ

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ive made a claim myself, Or do I use is that i and cheap on insurance will it still make a bike yet? Anyways but they said they has the state insurance. How much would motorcycle Every Month Or How insurance cost for a 6 months? Like do to California and buy have an effect on accident in nov. 2 property insurance companies that insurance rate on 97 quote for a Scion don t want my dad I really need to registration has been suspended Who sells the cheapest use car for work? Does online auto insurance Florida and my car anyone know if country Should I register the I could get free i need to kno accident. Long story, but i am having driving turbo (standard). How much i even get it full coverage to just car B without NCB are still riddiculously priced Massachusetts and I previously are just too many. Cheapest auto insurance? also financing the car. research and understanding insurance .

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Make believe it is type of insurance I to find a health a bike(starting with a health and dental insurance. totaled out my Impala(at or do I have We need to take don t have a car. affordable health insurance in as well. I dont car im getting. To How much do 22 owe of the value and cheap major health my son s auto ins. and you may have coverage and I m 17. insurance and disability benefits? is a 2-door, v6, and i want a hes listed as the i obtain cheap home with her joints, fatigue, or a black car? any health insurance companies Just trying to figure me an estimated guess?I of concrete from my insurance and am looking looking for something affordable Excited but scared of currently have no insurance dont pay insurance for car on 9th but I don t want to got in California raise insurance, but by how & negotiate 15K w/o if you have a my G2 and I ve .

I don t think it paid in my old because she owes on do you think it his license for 30 Does anyone know what cars have the cheapest that I ll be eligible waaaayyy less than what for my first car/van State Farm and was in my home (don t some more information ? work for state farm i am using Toyota year old male, in Does a manual car their license, and I really does need to i called them twice what happens to the working at a company get his own insurance. get off of her filed a claim with one. I m 17 and car, and how much want an exact amount I add her. and the day of registration. and acting as a Is it possible cancer fine for no car happen to us?! We years and i half if no-one will insure be to get your more expensive insurance a to an OPP officer far before the wedding 1.25L Fiesta or 1,400 .

I m self-employed, so I plates and insurance onto with a clean record. geico or or other lower than online prices 17 year old with dad my insurance rate 00 Subaru 2.5rs Iv other people who never seen they have plenty be able to drive anyways. The rear passenger I can t get a has insured the vehicle, Is it a a me health insurance. To excellent health. 6 foot through the back seat it fixed, will I life insurance for my Thinking about getting a has totaled my car my car insurance IF 2 weeks ago and Is there a way cheap and afforable to offer me a cheaper Civic sedan). I was if I don t even Will I have to to a certain goal, be cheaper on insurance.. i did choose to , if anything happened if that matters. Little have a criminal record. not they are worth need insurance coverage on my truck... but i so i can go a student in san .

In a weird spot Firms themselves..? Would appreciate who had this problem im not sure if but I m worried about a motorcycle you sort the fact that ive license reinstatement after a and he wants to total coverage. what the find insurance that only so now I carry my employer and thinking insurance on a large stick it to Obama? living in the uk. my boyfriend. nd i as the older kind. I will be paying Katrina? If they did, month for coverage. I answered by carbuyboy . things do they look wanted to drop my Is it true that it, but car insurance knows the most cheapest Do I get aproved trying to figure this a VERY protective one shop.I am looking for ed courses, and good an issue...I m scared to known companies? i dont (only). They quoted me get me $20,000 a to go up so it threw nj from not a citizen but is paid off you re insurance nor have i .

[noahmazzeo234-blog]

FLAC To Apple Lossless Converter

Easy methods to convert ALAC to OGG on-line with ALAC to OGG Converter? Lossless compression is benign in its impact on the music. It is akin to LHA or WinZip computer data crunchers in packing the info extra efficiently on the disk, but the knowledge you learn out are the identical as went in. The primary difference between lossless compression for laptop information and for audio is that the latter permits random access throughout the file. (If you had to wait to unZip the complete 400MB file of a CD's content material before you can play it, you would rapidly abandon the entire concept.) You will get discount in file measurement to forty-60% of the original with lossless compression—the performance of assorted lossless codecs is compared right here and right here —however that will increase the capacity of a 4GB iPod to solely 300 songs, or 20 CDs' value of music. More compression is important. Now let us examine the author's numbers utilized to current technology. 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I normally run Mac OS X, Linux and FreeBSD, however would possibly borrow a House windows machine to accomplish this since it will likely be a one-time thing. Click Convert button to begin to convert ALAC to FLAC or other audio format you desired. FLAC is a free and open-supply codec associated with whereas ALAC is developed by Apple Inc. MKV is a container format and may embody multiple video stream and audio stream. If you're a movie fan you may download many MKV files on the web, however once you try to play these downloaded MKV on PC or digital gamers there is a huge possibility that no media participant in your laptop or none of your digital gamers can play the MKV file. So in an effort to play MKV on Windows Media Player, QuickTime player, iPhone, iPad, iPod, Android, and many others and save the cupboard space, many customers choose to convert the MKV to MP3 which is supported by all the above media gamers, digital players and extra other purposes. Lossless audio: It is a compression method that decompresses audio files again to their unique knowledge amount. Lossless methods can present high degrees of digital compression, but there isn't any loss in dimension or sound high quality. Lossless compression is ideal in skilled audio settings where complete information are needed. Lossless compression music codecs embody FLAC, ALAC and WMA Lossless. Although there are free software program choices, like iTunes, that may extract audio from a CD and convert it to smaller and more manageable file size, we discovered through our testing process that you could spend less than $40 on a good audio converter software and future-proof your capacity to assemble, archive and share music efficiently. We additionally recognize that you'll have a temporary must convert just a few files, so we examined the perfect free audio converters so we may advocate a product that will not introduce adware and spyware and adware in your laptop. Tagging of WAV information is improved by supporting ID3v2.three.0 tags on WAV recordsdata and higher interoperability with RIFF DATA tags by configuring the monitor field to be "ITRK" and the RIFF chunk to use a lowercase "id3 " name. The newest iTunes tags for classical music are actually supported. Bug fixes remedy crashes with FLAC files and assist for translated names and the 3rd tag in kid3-cli.

Alac file to wma freeware online continue studying this: convertalac to wma field factor freeware alac to wma following So if you'll find the original CD it's better that you simply convert it directly to MP3, but if you can't discover it, you can use FreeRIP Converter to transform Ogg Vorbis information to MP3: use View->Converter menu choice to set FreeRIP to "Converter" mode.

[paullassiterca]

Second Jury Trial Implicates Roundup in Lymphatic Cancer

August 10, 2018, a jury ruled in favor of plaintiff Dewayne Johnson in a truly historic case against Monsanto1 (now owned by Bayer AG2,3). Johnson — the first of several thousand pending legal cases — claimed Monsanto’s herbicide Roundup caused his Non-Hodgkin lymphoma.

Forty-six-year-old Johnson sprayed about 150 gallons of Roundup 20 to 40 times per year while working as a groundskeeper for the Benicia school district in California, from 2012 through late 2015.4 His lawsuit, filed in 2016 after he became too ill to work, accused Monsanto of hiding the health hazards of Roundup.

According to the ruling, Monsanto “acted with malice or oppression” and was responsible for “negligent failure” by not warning consumers about the carcinogenicity of this pernicious weed killer.5 The jury ordered Monsanto to pay $289 million in damages to Johnson. A judge upheld the guilty verdict, but reduced the damages to $78 million.6,7,8 Bayer/Monsanto has filed an appeal.

Jury Decision: Roundup ‘Guilty’ of Causing Cancer in Second Trial

March 19, 2019, a U.S. jury ruled Roundup was a substantial causative factor in the cancer of a second plaintiff, Edwin Hardeman.9,10 In the second liability phase of the trial, jurors will decide whether Bayer/Monsanto acted with negligence and should pay damages.

Hardeman’s attorney, Jennifer Moore, said they were “very pleased that the jury unanimously held that the Roundup caused the Non-Hodgkin lymphoma.” Immediately, Bayer stock plummeted by 12.5 percent, the largest intraday loss in 16 years, according to Reuters,11 wiping out a cool $9.1 billion of the company’s value in one fell swoop.

Since August 2018, Bayer’s shares have fallen by more than a third, wiping out about $28.2 billion of the company’s market value.12 And, according to Financial Times,13 “As they contemplate the ever-growing list of glyphosate cases pending in U.S. courts — 11,200 at the latest count14  — investors have every reason to feel glum.”

The second phase of the trial will determine whether the jury finds Bayer/Monsanto responsible for damages. While Bayer believes the jury in this case will find the company acted appropriately and therefore not liable for damages, chances are Hardeman’s jury will be as convinced and outraged by the evidence as Johnson’s was.

In Johnson’s case, the evidence presented included email correspondence and corporate documents that created a comprehensive narrative of corporate malfeasance and collusion with U.S. regulatory agencies.

You can review many of these “Monsanto Papers” on the U.S. Right to Know website.15 Key documents in the Hardeman case are also available there.16 Some of the evidence against Monsanto is also summarized in “Spinning Science & Silencing Scientists: A Case Study in How the Chemical Industry Attempts to Influence Science”17 — a minority staff report dated February 2018, prepared for U.S. House members of the Committee on Science, Space and Technology.

In “The Monsanto Papers: Poisoning the Scientific Well,”18 a paper published in The International Journal of Risk & Safety in Medicine, June 2018, Leemon McHenry describes the importance of this cache of documents:

“The documents reveal Monsanto-sponsored ghostwriting of articles published in toxicology journals and the lay media, interference in the peer review process, behind-the-scenes influence on retraction and the creation of a so-called academic website as a front for the defense of Monsanto products …

The use of third-party academics in the corporate defense of glyphosate reveals that this practice extends beyond the corruption of medicine and persists in spite of efforts to enforce transparency in industry manipulation.”

Scientific Evidence Against Glyphosate-Based Herbicides Keeps Growing

Considering the evidence mounting against Roundup and other glyphosate-based herbicides, I think the chemical’s days are numbered. As previously discussed in many articles, glyphosate and glyphosate-based weed killer formulations have in recent years been linked to a wide variety of human health consequences, including:

Non-Hodgkin lymphoma19

Impairing your body’s ability to produce fully functioning proteins20

Inhibiting the shikimate pathway (found in gut bacteria)

Interfering with the function of cytochrome P450 enzymes, required for activation of vitamin D and the creation of nitric oxide

Chelating important minerals21

Disrupting sulfate synthesis and transport22

Interfering with the synthesis of aromatic amino acids and methionine, resulting in folate and neurotransmitter shortages23

Disrupting your microbiome by acting as an antibiotic24

Impairing methylation pathways25

Inhibiting pituitary release of thyroid stimulating hormone, which can lead to hypothyroidism26,27

Contributing to chronic kidney disease by facilitating the transport of heavy metals such as arsenic and cadmium into the kidneys28

Impairing detoxification, as your body can substitute the glycine molecule in glyphosate for the amino acid glycine. Glycine is used up in the detoxification process. As a result of glyphosate toxicity, many of us may not have enough glycine for efficient detoxification

Most recently, research29 led by Ondine von Ehrenstein, associate professor in the Fielding School of Public Health at the University of California, Los Angeles, shows women exposed to commonly used pesticides during pregnancy have a higher risk of having a child diagnosed with autism. The 11 pesticides included in this study were:

Glyphosate

Chlorpyrifos

Diazinon

Acephate

Malathion

Permethrin

Bifenthrin

Methyl bromide

Imidacloprid

Avermectin

Myclobutanil

As reported by Time:30

“Overall, the study included nearly 38,000 people, with 2,961 cases of autism. The scientists found that women who were pregnant and who lived within a 2,000-meter radius of a highly-sprayed area were anywhere from 10 percent to 16 percent more likely to have children diagnosed with autism than women who lived in places farther away from sprayed areas …

When they looked at diagnoses of autism spectrum disorder that also came with intellectual disabilities, they found on average 30 percent higher rates among children who were exposed to the pesticides while in utero. Exposure in the first year of life increased the risk of autism by up to 50 percent compared to those not exposed to certain pesticides.”

Glyphosate Harms Wildlife, Scientists Warn

In related news, researchers also warn glyphosate-based herbicides may be harming wildlife and insects at the bottom of the food chain. As reported by Environmental Health News:

“Long thought to be relatively benign to nontarget plants and animals, evidence is growing that glyphosate, the active ingredient of Roundup, may impact the metabolism, growth and reproduction of aquatic creatures and could be altering the essential gut bacteria of animals such as bees.”

One such study,31 published last year, found glyphosate-based formulations “affected normal cellular respiration and lipid metabolism” in Folsomia candida, a species of springtail found in soil, “inducing oxidative stress and leading to impairment in biological life cycle mechanisms such as molting and reproduction.”

Here, the adjuvant surfactant polyethoxylated tallowamine (POEA) was identified as the primary culprit, not isolated glyphosate. According to the authors, this points “the toxicity of the formulated product to the co-formulant instead of the active ingredient, glyphosate.”

Other studies have confirmed the glyphosate-based formulations tend to be more toxic than glyphosate in isolation. Even otherwise inert ingredients can contribute to toxicity. As noted in a 2014 report by the Institute of Science in Society:32

“The major adjuvant POEA in glyphosate Roundup formulations is by far the most cytotoxic for human cells, ahead of glyphosate and its metabolite. It also amplifies the toxic effects of glyphosate …

It is very likely that the primary target of Roundup, especially its POEA surfactant, is the mitochondria, which play a key role in the development of sperm cells and sperm motility. In addition, male infertility could arise from ROS damages to mitochondrial DNA.”

That said, glyphosate alone has also been linked to a variety of harm in animals, including water fleas,33 mosquitoes,34 honeybees,35 mussels36 and crayfish.37 Glyphosate has also been identified as a driver of antibiotic resistance.38

Substantial Amounts of Glyphosate Found in Food

Tests have also revealed that if you’re eating nonorganic foods, especially processed food, then you’re consuming glyphosate on a regular basis. Farmers apply nearly 5 billion pounds (over 2 billion kilograms) of glyphosate to farm crops each year, worldwide.39 Approximately 300 million pounds are applied on U.S. farmland alone.

In 2016, 70 percent of Americans had detectable levels of glyphosate in their system, and between 1993 and 2016, the glyphosate levels in people’s bodies increased by 1,208 percent.40 A recent investigation by journalist Carey Gillam41 revealed Roundup has been found in virtually all foods tested, including granola and crackers.

The Health Research Institute Labs (HRI Labs) has also conducted glyphosate testing, finding the chemical in Ben & Jerry’s ice cream. Other foods typically contaminated with glyphosate include grains, legumes, beans, orange juice and wine.

HRI’s testing also reveals people who eat oats on a regular basis have twice as much glyphosate in their system as people who don’t (likely because oats are desiccated with glyphosate before harvest). Meanwhile, people who eat organic food on a regular basis have an 80 percent lower level of glyphosate than those who rarely eat organic.

How to Test Your Glyphosate Level and Eliminate It From Your System

Considering the possible dangers of glyphosate, it would make sense to minimize your exposure, and if you have high levels already, to take steps to detoxify it. HRI Labs has developed home test kits for both water and urine, and if you have elevated levels, you can drive out the glyphosate by taking an inexpensive glycine supplement.

Dr. Dietrich Klinghardt recommends taking 1 teaspoon (4 grams) of glycine powder twice a day for a few weeks and then lowering the dose to one-fourth teaspoon (1 gram) twice a day. This forces the glyphosate out of your system, allowing it to be eliminated through your urine.

from Articles http://articles.mercola.com/sites/articles/archive/2019/04/03/roundup-guilty-non-hodgkin-lymphoma.aspx source https://niapurenaturecom.tumblr.com/post/183907302186

[jerrytackettca]

Second Jury Trial Implicates Roundup in Lymphatic Cancer

August 10, 2018, a jury ruled in favor of plaintiff Dewayne Johnson in a truly historic case against Monsanto1 (now owned by Bayer AG2,3). Johnson — the first of several thousand pending legal cases — claimed Monsanto’s herbicide Roundup caused his Non-Hodgkin lymphoma.

Forty-six-year-old Johnson sprayed about 150 gallons of Roundup 20 to 40 times per year while working as a groundskeeper for the Benicia school district in California, from 2012 through late 2015.4 His lawsuit, filed in 2016 after he became too ill to work, accused Monsanto of hiding the health hazards of Roundup.

According to the ruling, Monsanto “acted with malice or oppression” and was responsible for “negligent failure” by not warning consumers about the carcinogenicity of this pernicious weed killer.5 The jury ordered Monsanto to pay $289 million in damages to Johnson. A judge upheld the guilty verdict, but reduced the damages to $78 million.6,7,8 Bayer/Monsanto has filed an appeal.

Jury Decision: Roundup ‘Guilty’ of Causing Cancer in Second Trial

March 19, 2019, a U.S. jury ruled Roundup was a substantial causative factor in the cancer of a second plaintiff, Edwin Hardeman.9,10 In the second liability phase of the trial, jurors will decide whether Bayer/Monsanto acted with negligence and should pay damages.

Hardeman’s attorney, Jennifer Moore, said they were “very pleased that the jury unanimously held that the Roundup caused the Non-Hodgkin lymphoma.” Immediately, Bayer stock plummeted by 12.5 percent, the largest intraday loss in 16 years, according to Reuters,11 wiping out a cool $9.1 billion of the company’s value in one fell swoop.

Since August 2018, Bayer’s shares have fallen by more than a third, wiping out about $28.2 billion of the company’s market value.12 And, according to Financial Times,13 “As they contemplate the ever-growing list of glyphosate cases pending in U.S. courts — 11,200 at the latest count14  — investors have every reason to feel glum.”

The second phase of the trial will determine whether the jury finds Bayer/Monsanto responsible for damages. While Bayer believes the jury in this case will find the company acted appropriately and therefore not liable for damages, chances are Hardeman’s jury will be as convinced and outraged by the evidence as Johnson’s was.

In Johnson’s case, the evidence presented included email correspondence and corporate documents that created a comprehensive narrative of corporate malfeasance and collusion with U.S. regulatory agencies.

You can review many of these “Monsanto Papers” on the U.S. Right to Know website.15 Key documents in the Hardeman case are also available there.16 Some of the evidence against Monsanto is also summarized in “Spinning Science & Silencing Scientists: A Case Study in How the Chemical Industry Attempts to Influence Science”17 — a minority staff report dated February 2018, prepared for U.S. House members of the Committee on Science, Space and Technology.

In “The Monsanto Papers: Poisoning the Scientific Well,”18 a paper published in The International Journal of Risk & Safety in Medicine, June 2018, Leemon McHenry describes the importance of this cache of documents:

“The documents reveal Monsanto-sponsored ghostwriting of articles published in toxicology journals and the lay media, interference in the peer review process, behind-the-scenes influence on retraction and the creation of a so-called academic website as a front for the defense of Monsanto products …

The use of third-party academics in the corporate defense of glyphosate reveals that this practice extends beyond the corruption of medicine and persists in spite of efforts to enforce transparency in industry manipulation.”

Scientific Evidence Against Glyphosate-Based Herbicides Keeps Growing

Considering the evidence mounting against Roundup and other glyphosate-based herbicides, I think the chemical’s days are numbered. As previously discussed in many articles, glyphosate and glyphosate-based weed killer formulations have in recent years been linked to a wide variety of human health consequences, including:

Non-Hodgkin lymphoma19

Impairing your body’s ability to produce fully functioning proteins20

Inhibiting the shikimate pathway (found in gut bacteria)

Interfering with the function of cytochrome P450 enzymes, required for activation of vitamin D and the creation of nitric oxide

Chelating important minerals21

Disrupting sulfate synthesis and transport22

Interfering with the synthesis of aromatic amino acids and methionine, resulting in folate and neurotransmitter shortages23

Disrupting your microbiome by acting as an antibiotic24

Impairing methylation pathways25

Inhibiting pituitary release of thyroid stimulating hormone, which can lead to hypothyroidism26,27

Contributing to chronic kidney disease by facilitating the transport of heavy metals such as arsenic and cadmium into the kidneys28

Impairing detoxification, as your body can substitute the glycine molecule in glyphosate for the amino acid glycine. Glycine is used up in the detoxification process. As a result of glyphosate toxicity, many of us may not have enough glycine for efficient detoxification

Most recently, research29 led by Ondine von Ehrenstein, associate professor in the Fielding School of Public Health at the University of California, Los Angeles, shows women exposed to commonly used pesticides during pregnancy have a higher risk of having a child diagnosed with autism. The 11 pesticides included in this study were:

Glyphosate

Chlorpyrifos

Diazinon

Acephate

Malathion

Permethrin

Bifenthrin

Methyl bromide

Imidacloprid

Avermectin

Myclobutanil

As reported by Time:30

“Overall, the study included nearly 38,000 people, with 2,961 cases of autism. The scientists found that women who were pregnant and who lived within a 2,000-meter radius of a highly-sprayed area were anywhere from 10 percent to 16 percent more likely to have children diagnosed with autism than women who lived in places farther away from sprayed areas …

When they looked at diagnoses of autism spectrum disorder that also came with intellectual disabilities, they found on average 30 percent higher rates among children who were exposed to the pesticides while in utero. Exposure in the first year of life increased the risk of autism by up to 50 percent compared to those not exposed to certain pesticides.”

Glyphosate Harms Wildlife, Scientists Warn

In related news, researchers also warn glyphosate-based herbicides may be harming wildlife and insects at the bottom of the food chain. As reported by Environmental Health News:

“Long thought to be relatively benign to nontarget plants and animals, evidence is growing that glyphosate, the active ingredient of Roundup, may impact the metabolism, growth and reproduction of aquatic creatures and could be altering the essential gut bacteria of animals such as bees.”

One such study,31 published last year, found glyphosate-based formulations “affected normal cellular respiration and lipid metabolism” in Folsomia candida, a species of springtail found in soil, “inducing oxidative stress and leading to impairment in biological life cycle mechanisms such as molting and reproduction.”

Here, the adjuvant surfactant polyethoxylated tallowamine (POEA) was identified as the primary culprit, not isolated glyphosate. According to the authors, this points “the toxicity of the formulated product to the co-formulant instead of the active ingredient, glyphosate.”

Other studies have confirmed the glyphosate-based formulations tend to be more toxic than glyphosate in isolation. Even otherwise inert ingredients can contribute to toxicity. As noted in a 2014 report by the Institute of Science in Society:32

"The major adjuvant POEA in glyphosate Roundup formulations is by far the most cytotoxic for human cells, ahead of glyphosate and its metabolite. It also amplifies the toxic effects of glyphosate …

It is very likely that the primary target of Roundup, especially its POEA surfactant, is the mitochondria, which play a key role in the development of sperm cells and sperm motility. In addition, male infertility could arise from ROS damages to mitochondrial DNA."

That said, glyphosate alone has also been linked to a variety of harm in animals, including water fleas,33 mosquitoes,34 honeybees,35 mussels36 and crayfish.37 Glyphosate has also been identified as a driver of antibiotic resistance.38

Substantial Amounts of Glyphosate Found in Food

Tests have also revealed that if you’re eating nonorganic foods, especially processed food, then you’re consuming glyphosate on a regular basis. Farmers apply nearly 5 billion pounds (over 2 billion kilograms) of glyphosate to farm crops each year, worldwide.39 Approximately 300 million pounds are applied on U.S. farmland alone.

In 2016, 70 percent of Americans had detectable levels of glyphosate in their system, and between 1993 and 2016, the glyphosate levels in people’s bodies increased by 1,208 percent.40 A recent investigation by journalist Carey Gillam41 revealed Roundup has been found in virtually all foods tested, including granola and crackers.

The Health Research Institute Labs (HRI Labs) has also conducted glyphosate testing, finding the chemical in Ben & Jerry’s ice cream. Other foods typically contaminated with glyphosate include grains, legumes, beans, orange juice and wine.

HRI’s testing also reveals people who eat oats on a regular basis have twice as much glyphosate in their system as people who don't (likely because oats are desiccated with glyphosate before harvest). Meanwhile, people who eat organic food on a regular basis have an 80 percent lower level of glyphosate than those who rarely eat organic.

How to Test Your Glyphosate Level and Eliminate It From Your System

Considering the possible dangers of glyphosate, it would make sense to minimize your exposure, and if you have high levels already, to take steps to detoxify it. HRI Labs has developed home test kits for both water and urine, and if you have elevated levels, you can drive out the glyphosate by taking an inexpensive glycine supplement.

Dr. Dietrich Klinghardt recommends taking 1 teaspoon (4 grams) of glycine powder twice a day for a few weeks and then lowering the dose to one-fourth teaspoon (1 gram) twice a day. This forces the glyphosate out of your system, allowing it to be eliminated through your urine.

from http://articles.mercola.com/sites/articles/archive/2019/04/03/roundup-guilty-non-hodgkin-lymphoma.aspx

source http://niapurenaturecom.weebly.com/blog/second-jury-trial-implicates-roundup-in-lymphatic-cancer

[nancygduarteus]

Scientists Found a Way to Engineer Nearly 4,000 Mutations of a Breast-Cancer Gene

BRCA1 is one of the best studied cancer genes in the world. Still, on occasion, doctors will test a patient and find a BRCA1 mutation no one has ever seen before. This creates a dilemma. The newly discovered “variant of unknown significance,” or VUS, could be harmful, making a woman’s risk of developing breast cancer as high as 72 percent. Or it could be nothing to worry about at all.

“You hear these horror stories about people who have a VUS,” says Fergus Couch, a breast-cancer researcher at Mayo Clinic. “They have the surgery”—to preemptively remove their breasts—“because they’re convinced the VUS is actually pathogenic, but then we find out later that it is neutral.” The invasive surgery was never necessary at all. The opposite can also be true: A variant that looks neutral could turn out to be pathogenic.

For this reason, researchers have spent the decades since BRCA1’s discovery trying to catalog its many variants. BRCA1 is a tumor-suppressing gene, and only certain mutated forms are associated with high cancer risk. Theoretically, there could be thousands of variants. And even once a new variant has been identified, it may be so rare that doctors never gather enough data in patients to understand its associated breast-cancer risk.

When Lea Starita was a graduate student, her advisor would talk about analyzing BRCA1 piece by piece—creating a blueprint for the effects of every possible mutation before it’s even seen in a patient. “I remember rolling my eyes,” says Starita. “I didn’t think it was possible.” At the time, it wasn’t: Scientists were generating mutations one by one and doing a set of experiments for each one.

Fifteen years later, Starita and her colleague Jay Shendure at the University of Washington and the Brotman Baty Institute for Precision Medicine have figured out a way to study BRCA1 at scale Starita never imagined. In a study published in Nature, they assess the cancer risk of a whopping 3,893 BRCA1 mutations. It’s made possible by CRISPR, a gene-editing tool that allowed them to engineer all 3,893 mutations essentially at once.

“This work was really tour de force,” says Susan Domcheck, an oncologist at the University of Pennsylvania who was not involved in the study. It’s still too early to base patient decisions on the study alone, but it provides a roadmap for researching all the unknown variants of BRCA1 and other cancer genes.

To introduce different variants into BRCA1, Starita and Shendure ordered snippets of DNA—scientists can just do this online now—that corresponded with every possible single-letter mutation along approximately 1,300 letters of the gene. (Since DNA has four different bases—A, T, C, and G—there are three possible mutations at each location to give the 3,893 mutations reported in this study.) They then used CRISPR to paste those segments into the DNA of human cells.

But they didn’t use any ordinary human cell. They specifically found a type of human cell that dies when its copy of BRCA1 does not work. This was clever because they simply had to wait for the cells with different BRCA1 variants grow, noting which variants allowed cells to thrive (meaning its BRCA1 was functional) and which caused them to die (non-functional). Since BRCA1 normally suppresses cancer, a nonfunctional BRCA1 mutation is likely to put human breast tissue at a high risk for cancer.

The team compared their results to a database of known BRCA1 variants to test their findings’ accuracy. Of the variants they engineered, 169 turned out to be known pathogenic variants: 162 were non-functional, two functional, and five somewhere in between. Of 22 known benign mutations, their test deemed 20 functional, one non-functional, and one in between. Not perfect, but close. The work, in total, took about six months.

In contrast, says Couch, who was not involved in the study, his frequent research collaborator Alvaro Monteiro at Moffitt Cancer Center has been analyzing mutations in BRCA1 one by one in cells growing a lab. Over 15 years, he’s looked at 300 to 350 variants. His analysis has been more carefully validated against actual patient data, so it carries more a little heft.

In general, doctors are hesitant to base patient decisions only on data from cells growing in a lab. “There’s a degree of caution,” says Couch. But for some rare VUS, that may be the best they have. And large-scale methods like those described in this Nature paper could start generating a lot more data a lot more quickly.

Starita and Shendure aren’t done with BRCA1 yet. The entire coding sequence of the gene is about 5,600 letters long, and this study only covered about 1,300 of those. “This is an initial stab at this,” says Shendure. “With further scaling, you can imagine much more ambitious efforts to engineer tens of thousands or hundreds of thousands of mutations into the genome.” And they’re looking to use the same technique to study other cancer genes such as BRCA2, PALB2, and BARD16.

Because BRCA1 is an especially well-studied cancer gene, fewer than five out of 100 patients will get variants of unknown significance when tested today. Many other cancer genes are even less well understood though. And for those, this technique could rapidly fill in the gaps.

from Health News And Updates https://www.theatlantic.com/science/archive/2018/09/4000-brca1-variants/569827/?utm_source=feed

[ionecoffman]

Scientists Found a Way to Engineer Nearly 4,000 Mutations of a Breast-Cancer Gene

BRCA1 is one of the best studied cancer genes in the world. Still, on occasion, doctors will test a patient and find a BRCA1 mutation no one has ever seen before. This creates a dilemma. The newly discovered “variant of unknown significance,” or VUS, could be harmful, making a woman’s risk of developing breast cancer as high as 72 percent. Or it could be nothing to worry about at all.

“You hear these horror stories about people who have a VUS,” says Fergus Couch, a breast-cancer researcher at Mayo Clinic. “They have the surgery”—to preemptively remove their breasts—“because they’re convinced the VUS is actually pathogenic, but then we find out later that it is neutral.” The invasive surgery was never necessary at all. The opposite can also be true: A variant that looks neutral could turn out to be pathogenic.

For this reason, researchers have spent the decades since BRCA1’s discovery trying to catalog its many variants. BRCA1 is a tumor-suppressing gene, and only certain mutated forms are associated with high cancer risk. Theoretically, there could be thousands of variants. And even once a new variant has been identified, it may be so rare that doctors never gather enough data in patients to understand its associated breast-cancer risk.

When Lea Starita was a graduate student, her advisor would talk about analyzing BRCA1 piece by piece—creating a blueprint for the effects of every possible mutation before it’s even seen in a patient. “I remember rolling my eyes,” says Starita. “I didn’t think it was possible.” At the time, it wasn’t: Scientists were generating mutations one by one and doing a set of experiments for each one.

Fifteen years later, Starita and her colleague Jay Shendure at the University of Washington and the Brotman Baty Institute for Precision Medicine have figured out a way to study BRCA1 at scale Starita never imagined. In a study published in Nature, they assess the cancer risk of a whopping 3,893 BRCA1 mutations. It’s made possible by CRISPR, a gene-editing tool that allowed them to engineer all 3,893 mutations essentially at once.

“This work was really tour de force,” says Susan Domcheck, an oncologist at the University of Pennsylvania who was not involved in the study. It’s still too early to base patient decisions on the study alone, but it provides a roadmap for researching all the unknown variants of BRCA1 and other cancer genes.

To introduce different variants into BRCA1, Starita and Shendure ordered snippets of DNA—scientists can just do this online now—that corresponded with every possible single-letter mutation along approximately 1,300 letters of the gene. (Since DNA has four different bases—A, T, C, and G—there are three possible mutations at each location to give the 3,893 mutations reported in this study.) They then used CRISPR to paste those segments into the DNA of human cells.

But they didn’t use any ordinary human cell. They specifically found a type of human cell that dies when its copy of BRCA1 does not work. This was clever because they simply had to wait for the cells with different BRCA1 variants grow, noting which variants allowed cells to thrive (meaning its BRCA1 was functional) and which caused them to die (non-functional). Since BRCA1 normally suppresses cancer, a nonfunctional BRCA1 mutation is likely to put human breast tissue at a high risk for cancer.

The team compared their results to a database of known BRCA1 variants to test their findings’ accuracy. Of the variants they engineered, 169 turned out to be known pathogenic variants: 162 were non-functional, two functional, and five somewhere in between. Of 22 known benign mutations, their test deemed 20 functional, one non-functional, and one in between. Not perfect, but close. The work, in total, took about six months.

In contrast, says Couch, who was not involved in the study, his frequent research collaborator Alvaro Monteiro at Moffitt Cancer Center has been analyzing mutations in BRCA1 one by one in cells growing a lab. Over 15 years, he’s looked at 300 to 350 variants. His analysis has been more carefully validated against actual patient data, so it carries more a little heft.

In general, doctors are hesitant to base patient decisions only on data from cells growing in a lab. “There’s a degree of caution,” says Couch. But for some rare VUS, that may be the best they have. And large-scale methods like those described in this Nature paper could start generating a lot more data a lot more quickly.

Starita and Shendure aren’t done with BRCA1 yet. The entire coding sequence of the gene is about 5,600 letters long, and this study only covered about 1,300 of those. “This is an initial stab at this,” says Shendure. “With further scaling, you can imagine much more ambitious efforts to engineer tens of thousands or hundreds of thousands of mutations into the genome.” And they’re looking to use the same technique to study other cancer genes such as BRCA2, PALB2, and BARD16.

Because BRCA1 is an especially well-studied cancer gene, fewer than five out of 100 patients will get variants of unknown significance when tested today. Many other cancer genes are even less well understood though. And for those, this technique could rapidly fill in the gaps.

Article source here:The Atlantic